General Function Checklist

1. Open the H_sapiens_Dec_2013 genome.
2. Type dmd in the Quick-search box.

• DMD is one of the suggested matches in the Quick-search drop-down.

• Mac
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Select DMD from the Quick-search drop-down to navigate to the longest known gene in the human genome, the dystrophin gene (DMD).

• IGB has navigated to the proper gene (dystrophin). You can do this by viewing the selection info for the gene. The gene's title should be "DMD". 
  *(Known issue. See IGBF-2625).

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Select the Advanced Search tab at the bottom of IGB.

• Search results for DMD are already being displayed in the tab.

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Select the top search result in the Advanced Search tab (ID: NM_001166237, Title: GSDMD).

• IGB has navigated to NM_001166237 in the gene GSDMD.

• Mac
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• Windows

Navigate to the following coordinates: chr1:30,688,740-31,361,080

• IGB has navigated to the proper location.

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1. In the Advanced Search tab at the bottom IGB, select Residues from the search type drop-down menu.
2. Enter "TAG|TAA|TGA" into the Advanced Search textbox and start the search.

• Verify that the search has located matches for "TAG", "TAA", and "TGA".

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Navigate to the following coordinates: chr1:30,992,236-30,992,279

• Residues have been highlighted on the sequence axis.

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1. Navigate to the following coordinates: chr1:30,688,740-31,361,080
2. In the Advanced Search tab at the bottom of IGB, select Residues from the search type drop-down menu.
3. Enter the following regular expressions (Note - clear the search results between each search (click the red X)):
   1. TATATttatg
   2. TATA.ttatg
   3. TATA..tatg
   4. TAT[AT]Tttatg
   5. [TA]{1,3}Tttatg
   6. TATAt*atg
   7. TATAT.*ttatg
   8. TATAT.*?ttatg

• Results show up for each search conducted above.

• Mac
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• Windows

1. In the Advanced Search tab, select Properties from the search type drop-down menu.
2. Enter false in the search text box.  

• There are many results and if you select one (double-click it) and go to the Selection Info panel, there is at least one attribute that has the value false.

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Enter family in the search text box.

• There are many results and all include the word family in the description. If not, check the selection info panel.

• Mac
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• Windows